CALL FOR PAPERS Integrative and Translational Physiology: Inflammation, Immunity, and Organ System Physiology Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene
نویسندگان
چکیده
Yuning Xiong,* Phyllis A. Svingen,* Olga O. Sarmento, Thomas C. Smyrk, Maneesh Dave, Sahil Khanna, Gwen A. Lomberk, Raul A. Urrutia, and William A. Faubion, Jr. Epigenetics and Chromatin Dynamics Laboratory, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; and Department of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota
منابع مشابه
Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.
Inducible gene expression, which requires chromatin remodeling on gene promoters, underlies the epigenetically inherited differentiation program of most immune cells. However, chromatin-mediated mechanisms that underlie these events in T regulatory cells remain to be fully characterized. Here, we report that inducibility of FOXP3, a key transcription factor for the development of T regulatory c...
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